Interaction of Et2SnCl2(phen) with Nucleotides
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry
- Vol. 27 (6) , 811-823
- https://doi.org/10.1080/00945719708000229
Abstract
The syntheses of mixed-ligand complexes formulated as Et2Sn-(phen)(AMP)Cl and Et2Sn(phen)(CMP)Cl as well as Et2Sn(phen)(GMP)Cl by reactions of the antitumor agent Et2SnCl2(phen) with equimolar amounts of nucleotides under biologically relevant conditions are described. The new complexes are characterized by microanalyses, UV, IR and 1H and 31P NMR spectra. These spectroscopic data suggest that one of the cis-chloro atoms in Et2SnCl2(phen) is substituted by a nucleotide and that Sn(IV) directly coordinates a phosphate group of the nucleotide.Keywords
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