DISAPPEARANCE RATE OF ADRENOCORTICOTROPIC HORMONE FROM RAT’S PLASMA AFTER INTRAVENOUS INJECTION1
- 1 March 1950
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 46 (3) , 261-264
- https://doi.org/10.1210/endo-46-3-261
Abstract
Male rats injd. intraven. with 5 mg. of pure ACTH were anesthetized and exanguinated at varying time intervals, and the ACTH content of the plasma detd. by the adrenal ascorbic acid depletion method of Sayers. Control plasma contained no measurable ACTH activity. One min. after injn., the level varied from 18-26 [mu]g./ml. of plasma and thereafter fell in a logarithmic fashion against time. The half time of disappearance of ACTH from plasma was 5.5 min. From the extrapolated level at zero time, it was estimated that only 6% of the injd. dose could be found in the plasma immediately after injn.Keywords
This publication has 2 references indexed in Scilit:
- METABOLIC ACTIONS AND FATE OF INTRAVENOUSLY ADMINISTERED ADRENOCORTICOTROPIC* HORMONE IN MAN†§Journal of Clinical Endocrinology & Metabolism, 1949
- THE ASSAY OF ADRENOCORTICOTROPHIC HORMONE BY THE ADRENAL ASCORBIC ACID-DEPLETION METHOD1Endocrinology, 1948