Acetylation of Sulfanilamide and Para-Aminobenzoic Acid in Diabetic Patients
- 27 August 1959
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 261 (9) , 440-442
- https://doi.org/10.1056/nejm195908272610907
Abstract
CHARALAMPOUS and Hegsted1 found that metabolic acetylation is impaired in experimental diabetes. They demonstrated this in alloxan-diabetic rats by the measurement of acetylated paraaminobenzoic acid (PABA) excreted in the urine after the intraperitoneal injection of PABA. It is known that this acetylation is carried out by acetyl coenzyme A. The present study was undertaken to ascertain whether such disturbances in acetylation occur in diabetic patients. Our results showed that no clearly significant impairment of acetylation is present in diabetes mellitus, in agreement with the findings of others.2 , 3 MethodNinety-two diabetic inpatients and 156 nondiabetic patients and healthy adults served as . . .Keywords
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