Chromosomal regions harboring genes for the work to femur failure in mice
- 21 March 2002
- journal article
- Published by Springer Nature in Functional & Integrative Genomics
- Vol. 1 (6) , 367-374
- https://doi.org/10.1007/s10142-001-0045-z
Abstract
The work to failure is defined as the maximum energy bone can absorb before breaking, and therefore is a direct test of the risk of fracture. To determine the genetic loci influencing work to failure, we have performed a high density genome-wide scan in 633 (MRL × SJL) F2 female mice. Five loci (P 2 mice. Of those, only the QTL on chromosome 9 was concordant with bone mineral density (BMD) QTLs. Eight significant interactions (P 2 variance (23%) to combined single QTL effects. Our results demonstrate that most of the genetic loci regulating work to failure are different from those for BMD in the 7-week-old female mice. If this is also true in humans, this finding will challenge the predictive value of BMD for the risk of fracture.Keywords
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