Phenotypic and Genetic Diversity of Invasive Pneumococcal Isolates Recovered from French Children
Open Access
- 1 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 40 (8) , 2994-2998
- https://doi.org/10.1128/jcm.40.8.2994-2998.2002
Abstract
We investigated the phenotypic and genetic diversity (by ribotyping) of Streptococcus pneumoniae isolates recovered from French children, by blood culture from meningitis-free patients ( n = 244) and by cerebrospinal fluid culture from patients with meningitis ( n = 154). Isolates belonging to serotypes associated with carriage and penicillin-resistant isolates were significantly more frequent in children under 2 years of age than in older children. The seven-valent pneumococcal conjugate vaccine covered 68% of strains associated with bacteremia and 61% of strains associated with meningitis in children under 2 years. Although some serotypes were recovered more frequently from children with bacteremia than from those with meningitis, no difference in the genetic backgrounds of the two groups of strains was found.Keywords
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