Selective Sugar Binding with a Synthetic Polyhydroxy Macrocycle. A Remarkable Selectivity for Fructose over Glucose

Abstract
D-Fructore, a ketohexose, is readily solubilized in CCl4 via complex formation with resorcinol-dodecanal cyclotetramer (1) , in marked contrast to D-glucose, a closely related aldohexose, which shows almost no affinity to 1. The affinity of fructose can be further enhanced by oligomeric modification of 1.

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