Radiochemistry, biochemistry, and kinetics of 131I‐metaiodobenzylguanidine (MIBG) and 123I‐MIBG: Clinical implications of the use of 123I‐MIBG
- 1 January 1987
- journal article
- research article
- Published by Wiley in Medical and Pediatric Oncology
- Vol. 15 (4) , 170-177
- https://doi.org/10.1002/mpo.2950150406
Abstract
Metaiodobenzylguanidine (MIBG) is actively concentrated in adrenergic neuroendocrine tissues and tumors by an active, energyand sodium‐dependent, high‐affinity, saturable mechanism. This has proved successful, when labeled with 131‐l or 123‐l, in scintigraphically depicting pheochromocytomas and neuroblastomas. For imaging purposes 123‐l has multiple advantages over 131‐l; the gamma ray energy is ideal for modern instruments the decay by electron capture limits the particulate emissions, and the short half‐life reduces the radiation burden. It is thus possible to use doses of 123‐I‐MIBC 20 times as large as doses of 131‐I‐MIBG with equivalent absorbed radiation doses. Disadvantages of 123‐I include the cost and difficulties in the regular delivery of this short‐lived radionuclide. For most imaging purposes 123‐I‐MIBC is the optimal agent if logistical problems in its sup ply can be overcome.Keywords
This publication has 20 references indexed in Scilit:
- Primary Extra-Adrenal Pheochromocytoma Positive I-123 MIBG Imaging with Negative I-131 MIBG ImagingClinical Nuclear Medicine, 1986
- Diagnosis and Treatment of a Carcinoid Tumor Using lodine-131 Meta-iodobenzylguanidineClinical Nuclear Medicine, 1986
- Radio-iodobenzylguanidine for the scintigraphic location and therapy of adrenergic tumorsSeminars in Nuclear Medicine, 1985
- 131I-meta-iodobenzylguanidine scintigraphy of neuroblastomasSeminars in Nuclear Medicine, 1985
- Familial extra-adrenal pheochromocytoma. A new syndromeArchives of internal medicine (1960), 1985
- SCINTIGRAPHIC IMAGING OF CARCINOID TUMOURS WITH 131I-METAIODOBENZYLGUANIDINEThe Lancet, 1984
- SCINTIGRAPHIC IMAGING OF NEUROBLASTOMA WITH [131I]IODOBENZYLGUANIDINEThe Lancet, 1984
- Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidinesJournal of Medicinal Chemistry, 1984
- Scintigraphic Localization of PheochromocytomaNew England Journal of Medicine, 1981
- Radiopharmaceuticals. 16. Halogenated dopamine analogs. Synthesis and radiolabeling of 6-iododopamine and tissue distribution studies in animalsJournal of Medicinal Chemistry, 1976