Mechanism of Death in Massive Fluid Infusion
- 1 June 1980
- journal article
- research article
- Published by Wolters Kluwer Health
- Vol. 20 (6) , 452-459
- https://doi.org/10.1097/00005373-198006000-00003
Abstract
To determine the effects of infusion of large volumes of crystalloid, a series of dogs was subjected to i.v. injection of oleic acid and moderate hypovolemic shock for 1 h. They were then resuscitated with 50 cm3/kg of Ringer''s lactate in 30 min followed by blood replacement, and another 50 cm3/kg of Ringer''s lactate over 1 h in 1 group and 2 h in the other. Of 9 receiving the fast infusion 8 died during the first 2 days, and 7 of 8 receiving the slow infusion lived for the full 3 days of the study. The dogs that died all had large intrapulmonary shunts and gross pulmonary edema at autopsy. Both groups received the same total amount of fluid. No differences in vascular pressure or cardiac function large enough to explain the differences were found. The critical difference was the rate of fluid infusion. The high-permeability pulmonary edema appears to have been aggravated by a transient pulmonary overperfusion induced by fast infusion of fluid.This publication has 0 references indexed in Scilit: