I. After-Effects of Repetitive Activity in a Nerve Ending

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Abstract
Repetitive mechanical stimulation causes depression of excitability in isolated Pacinian corpuscles: the mechanical threshold of the sense organ for producing nerve impulses increases progressively with time of repetitive stimulation. The effect is completely reversible; it can be elicited with repetitive stimuli of less than threshold strength. Within certain limits, the depression increases as a function of strength and frequency of the repetitive stimuli.