Critical chain length for the formation of the α-helix in the solid state. Synthesis and conformation of sequential oligopeptides and a polypeptide containing the sequenceL-leucyl-L-alanyl-L-leucylglycine
- 1 January 1977
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 1193-1196
- https://doi.org/10.1039/p19770001193
Abstract
A series of sequential oligopeptides and a polypeptide containing the sequence L-leucyl-L-alanyl-L-leucylglycine have been prepared by the fragment condensation method and the self-polycondensation method, respectively. The conformations of the peptides have been studied by far-i.r. spectroscopy and X-ray powder diffraction. The polypeptide and hexadecapeptide form an α-helix and the dodeca- and lower oligo-peptides a β-structure in the solid state. The results suggest that the critical chain length for the formation of an α-helix in the solid state is 16 residues.Keywords
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