Angiotensin I-Converting Enzyme Modulates Neutral Endopeptidase Activity in the Rat

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Abstract
Abstract — — Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were measured by fluorometry in homozygous rats (F 0 and F 2 ) for the Lewis microsatellite allele (LL, low ACE) and for the Brown Norway microsatellite allele (BB, high ACE). Plasma, lung, and aortic ACE activities in F 0 and F 2 were higher in BB rats than in LL rats ( P 0 and F 2 homozygous ( P r =−0.6 and −0.598 in F 0 and F 2 , respectively; P r =−0.77 in F 0 and r =−0.59 in F 2 , P r =−0.696 and −0.584 in F 0 and F 2 , respectively; P <0.03). In conclusion, genetically determined high ACE expression in rats is inversely related to tissue NEP activity, which could determine lower angiotensin-(1-7) tissue levels.