Synthesis of Substituted P-Stereogenic Vinylphosphine Oxides by Olefin Cross-Metathesis
- 7 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (18) , 3217-3220
- https://doi.org/10.1021/ol035011m
Abstract
Substituted vinylphosphine oxides have been prepared in good yield and exclusive (E)-olefin selectivity via olefin cross-metathesis using Grubbs and Hoveyda-type ruthenium catalysts. In addition, metathesis of chiral vinylphosphine oxides proceeds without racemization of the phosphorus chirality center, providing easy access to functionalized chiral nonracemic (E)-alkenylphosphine oxides.Keywords
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