Estrogen Receptors in Carcinoma of the Breast. A Comparison of the Dextran-coated Charcoal, Immunofluorescent, and Immunoperoxidase Technics

Open Access

1 July 1983

journal article
research article
Published by Oxford University Press (OUP) in American Journal of Clinical Pathology

Vol. 80 (1) , 1-5
https://doi.org/10.1093/ajcp/80.1.1

Abstract

This study compares the estrogen receptor (ER) content of 26 breast neoplasms as determined by dextran-coated charcoal (DCC), fluorescein-labeled estradiol conjugate (FITC) on frozen sections, and immunoperoxidase (IP) on sections of formalin-fixed, paraffin-embedded tissues. Concordance between results of the three technics was found in 16 (62%) cases. DCC and IP agreed in 18(69%) cases, DCC and FITC agreed in 22 (85%) cases, and IP agreed with FITC in 18 (69%) cases. Most of the concordant cases(15/16) were in patients with ER-positive neoplasms. The relative merits and applications of the three technics are discussed.

Keywords

This publication has 1 reference indexed in Scilit:

An Improved Histochemical Method for Detection of Estrogen Receptors in Mammary Cancer: Comparison with Biochemical Assay
American Journal of Clinical Pathology, 1979