Chemie und Stereochemie der Iridoide, XVI. EPC‐Synthese von (−)‐Hypnophilin
- 12 September 1991
- journal article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1991 (9) , 893-902
- https://doi.org/10.1002/jlac.1991199101154
Abstract
Chemistry and Stereochemistry of Iridoids, XVI. – EPC‐Synthesis of (−)‐HypnophilinThe synthesis of enantiomerically pure (−)‐hypnophilin (27) from (6R,7R)‐(−)‐7‐hydroxy‐3‐oxabicyclo[4.3.0]non‐1‐en‐9‐one (1) is described. 1 was obtained in 93% yield from catalpol, which is readily available from the aqueous sodium carbonate extract of Picrorhiza kurrooa (Scrophulariaceae). The specific rotation, MS, 1H‐ and 13C‐NMR data of synthetic (−)‐hypnophilin were identical with those of the natural product.Keywords
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