Mefloquine disposition in normals and in patients with severePlasmodium falciparum malaria
- 1 January 1989
- journal article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 14 (1) , 15-17
- https://doi.org/10.1007/bf03190836
Abstract
Mefloquine pharmacokinetics were studied in Kenyan African normal volunteers and in patients with severe acute attack ofPlasmodium falciparum malaria. Peak concentrations were achieved in both groups at 20 – 24 hours. The mean half-life of elimination was 385±150 hours (mean±SD) in normal subjects while in severe malaria it was 493 ±215 hours which was significantly longer (P<-0.001). The volume of distribution was significantly smaller in severe malaria where it was 30.76±10.501/kg (mean±SD) while in the normal subjects it was 40.90±20.70 1/kg (mean±SD) (P<-0.001). The total body clearance in severe malaria was 3.75±1.511/h (mean±SD). This was significantly lower than in the normal subjects where it was 5.15 ±1.50 1/h (mean±SD) (P<-0.001).Keywords
This publication has 7 references indexed in Scilit:
- The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism.British Journal of Clinical Pharmacology, 1985
- Practical therapeutics: treatment of complications of malaria.1984
- Development of mefloquine as an antimalarial drug. UNDP/World Bank/WHO update.1983
- Analysis of the antimalarial, mefloquine, in blood and plasma using high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1983
- Kinetic studies of mefloquine and of one of its metabolites, Ro 21-5104, in the dog and in man.1980
- Kinetics of a new antimalarial, mefloquineClinical Pharmacology & Therapeutics, 1979
- Quantitation of the Antimalarial Agent, Mefloquine, in Blood, Plasma, and Urine Using High-Pressure Liquid ChromatographyJournal of Pharmaceutical Sciences, 1977