Synthesis of 1-deaza-6-thioguanosine and 1-deaza-6-(methylthio)guanosine

1 January 1978

journal article
research article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 21 (1) , 112-114
https://doi.org/10.1021/jm00199a021

Abstract

A synthesis of 1-deaza-6-thioguanosine (8) and 1-deaza-6-(methylthio)guanosine (9) from 2-amino-6-chloro-1-deazapurine (4) is described. The reaction of the N2-acetyl derivative of 4 with 2,3,5-tri-O-acetyl-D-ribofuranosyl chloride in the presence of Linde 4A molecular sieve gave the blocked nucleoside 6. Deacetylation of 6 gave the chloro nucleoside 7 which was treated at high temperature with H2S and methyl mercaptan to give 8 and 9, respectively. The structure of 7 was confirmed by 1H NMR and by conversion to the cyclonucleoside. Compound 4 gave a 79% increase in life span in the L1210 mouse leukemia screen.

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