COMPARISON OF THE EFFECTS OF 11-PALMITOYLOXY-DELTA-9-TETRAHYDROCANNABINOL WITH DELTA-9-TETRAHYDROCANNABINOL AND 11-HYDROXY-DELTA-9-TETRAHYDROCANNABINOL ON THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME-SYSTEM

  • 1 January 1979
    • journal article
    • research article
    • Vol. 25  (3) , 525-535
Abstract
.DELTA.9-THC [tetrahydrocannabinol] and 11-OH-.DELTA.9-THC appear to in vivo affect the metabolism of both Type I and Type II substrates involving cytochrome P-450 as well as to affect the metabolism of a substrate requiring cytochrome P-448 in rats. These effects could not be observed significantly in in vitro experiments at the concentrations used. 11-Palmitoyloxy-.DELTA.9-THC does not appear to affect the metabolism of either Type I or Type II substrates but does appear to affect those substrates requiring P-448. It appears that the long-retained .DELTA.9-THC metabolite 11-palmitoyloxy-.DELTA.9-THC, as well as .DELTA.9-THC and 11-OH-.DELTA.9-THC, could alter in vivo the metabolism and activity of certain drugs and other foreign compounds.