INFLUENCE OF REPLACEMENT THERAPY ON THE INCREASED SUSCEPTIBILITY OF PROTEIN-DEFICIENT RATS TO TRAUMA

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Abstract
Rats, following periods of protein depletion, showed a decreased tolerance to trauma. Protein feeding restored normal tolerance but five or six days feeding was necessary to correct two weeks' depletion. The amount of protein consumed was an important factor when low levels of 0.08 to 0.68 gm. per day were used. Casein, Amigen, and wheat germ protein were effective for replacement. After protein depletion of one month or more, two or three weeks of protein feeding was required to restore normal tolerance. No individual amino acid was found to afford protection against trauma although a mixture of the essential amino acids in one case had some effect. Gelatin was an effective protein for replacement therapy. In a single experiment in which a mixture of glutamic acid and glycine of the same total nitrogen content as gelatin was administered, the same degree of protection was afforded as by gelatin.

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