In vitro Comparative Activity of Moxalactam, GR 20263, and N-Formimidoyl Thienamycin to Other Beta-Lactam Antibiotics and Tobramycin against Enterobacteriaceae and Staphylococci

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Abstract
The in vitro activities of moxalactam, GR 20263 and N-formimidoyl thienamycin were compared to those of cephalothin, cefazolin, cefamandole, cefoxitin and tobramycin against 152 strains of Enterobacteriaceae and staphylococci. Moxalactam, GR 20263 and N-formimidoyl thienamycin each had significantly improved activity toward the gram-negative organisms tested compared to the other .beta.-lactams and tobramycin. N-formimidoyl thienamycin was particularly impressive with respect to its activity toward Staphylococcus aureus and S. epidermidis as compared to moxalactam, GR 20263 and the older .beta.-lactam drugs.