EQUIVALENT EXPRESSION OF ENDOGENOUS MURINE LEUKEMIA VIRUS-RELATED GENES IN C3H-10T1/2 CELLS AND CHEMICALLY TRANSFORMED DERIVATIVE CELLS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 566-569
Abstract
The possibility that chemical carcinogens may induce enhanced expression of endogenous C-type RNA tumor virus genes in the absence of intact virus particle production was partially tested in a model system. This was accomplished by measuring the abundance and diversity of murine leukemia virus-related RNA sequences associated with the polyribosome fraction of nontransformed [mouse fibroblast] C3H/10T1/2 clone 8 cells and a 3-methylcholanthrene-transformed derivative clone. Although both clones are virus nonproducers, they contained significant amounts of poly(A)-containing murine leukemia virus-related RNA sequences; both the types and quantities of such sequences appear indistinguishable in both clones. The expression of the corresponding gene sequences into RNA is probably not related to the maintenance of the transformed state in these chemically transformed cells.

This publication has 0 references indexed in Scilit: