Phlogistic Activity of Secalonic Acid A

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Abstract
The phlogistic activity of secalonic acid A (S.A.A) was examined, isolation of which has recently been completed from Aspergillus ochraceus. S.A.A. gave rise to a biphasic increase of vascular permeability in the abdominal cavity of mice by intraperitoneal application in the dye-leakage test. The peak of this biphasic increase was at about 1 hr and about 18 hr respectively. Exudation of leucocyte in the abdominal fluid was remarkable in the delayed phase. S.A.A also induced intensive sustained edema in a rat paw by a single local application, making the edema last more than 10 days. Pus-like thick fluid and a scab developed around the injected position 3-4 days after the injection of S.A.A and lasted as similarly as edema did. The increased vascular permeability and the rat paw edema were inhibited by aspirin, hydrocortisone and indomethacin in appropriate doses. The phlogistic activity of S.A.A considerably decreased when its chemical structure was changed. The effect of the abdominal fluid exuded by intraperitoneal application of S.A.A was examined on the isolated preparation of guinea pig ileum, rat duodenum and rat estrous uterus, respectively. The fluid contracted the ileum but this activity was supposed not to be due to S.A.A itself.

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