The Effects of Passive CO2 Removal on Breathing Pattern in Humans

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Abstract
To determine the effects of nonventilatory CO2 transfer on breathing pattern, we monitored breathing in 7 patietns with renal failure undergoing hemodialysis. A respiratory inductance plethysmograph was used to record ventilation before and during dialysis. The duration of inspiration (T1), the duration of each breath (TTot) and the duty cycle (TI/TTot) did not differ for the pre-dialysis and the dialysis periods. In contrast, for each patient the mean tidal volume (VT) fell significantly during dialysis (p < 0.05), accounting for the reduction in minute ventilation (p < 0.005). The mean inspiratory flow rate (VT/TI) also fell (p < 0.01), demonstrating that nonventilatory CO2 loss via the dialysis bath is associated with reduced respiratory drive.

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