Parathyroid Hormone: Effects of the 3-34 Fragment in Vivo and Vitro
- 7 January 1983
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4580) , 67-69
- https://doi.org/10.1126/science.6849118
Abstract
The biologically active fragment ofparathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.Keywords
This publication has 12 references indexed in Scilit:
- Evidence for an endogenous parathyroid hormone-sensitive adenylate cyclase activatorBiochemical and Biophysical Research Communications, 1981
- Effects of calcium on a parathyroid hormone-sensitive adenylate cyclase inhibitorBiochemical and Biophysical Research Communications, 1980
- Precipitation of calcium phosphates under conditions of double diffusion in collagen and gels of gelatin and agarCalcified Tissue International, 1979
- Design and Synthesis of Parathyroid Hormone Analogues of Enhanced Biological ActivityEndocrine Research Communications, 1977
- Analysis of the requirements for parathyroid hormone action in renal membranes with the use of inhibiting analogues.Journal of Biological Chemistry, 1975
- Bovine Parathyroid Hormone: Minimum Chain Length of Synthetic Peptide Required for Biological ActivityEndocrinology, 1973
- Mode of action of parathyroid hormone and cyclic adenosine 3′,5′-monophosphate on renal tubular phosphate reabsorption in the dogJournal of Clinical Investigation, 1971
- Synthesis of a Biologically Active N-Terminal Tetratriacontapeptide of Parathyroid HormoneProceedings of the National Academy of Sciences, 1971
- Parathyroid function and the renal excretion of 3'5'-adenylic acid.Proceedings of the National Academy of Sciences, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951