Genetic Dissection of Transcriptional Regulation in Budding Yeast
Top Cited Papers
- 26 April 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5568) , 752-755
- https://doi.org/10.1126/science.1069516
Abstract
To begin to understand the genetic architecture of natural variation in gene expression, we carried out genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae . Over 1500 genes were differentially expressed between the parent strains. Expression levels of 570 genes were linked to one or more different loci, with most expression levels showing complex inheritance patterns. The loci detected by linkage fell largely into two categories: cis-acting modulators of single genes and trans-acting modulators of many genes. We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function.Keywords
This publication has 22 references indexed in Scilit:
- Yeast Cbk1 and Mob2 Activate Daughter-Specific Genetic Programs to Induce Asymmetric Cell FatesCell, 2001
- Widespread Collaboration of Isw2 and Sin3-Rpd3 Chromatin Remodeling Complexes in Transcriptional RepressionMolecular and Cellular Biology, 2001
- Genetical genomics: the added value from segregationTrends in Genetics, 2001
- Remodeling of Yeast Genome Expression in Response to Environmental ChangesMolecular Biology of the Cell, 2001
- Functional Discovery via a Compendium of Expression ProfilesCell, 2000
- Direct Allelic Variation Scanning of the Yeast GenomeScience, 1998
- Genome-wide expression monitoring in Saccharomyces cerevisiaeNature Biotechnology, 1997
- Filamentous growth in budding yeastTrends in Microbiology, 1997
- Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic ScaleScience, 1997
- Structural features in a brittle–ductile wax model of continental extensionNature, 1997