Donor-Cell Leukemia after Bone Marrow Transplantation for Severe Aplastic Anemia
- 5 September 1991
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 325 (10) , 710-713
- https://doi.org/10.1056/nejm199109053251007
Abstract
ACUTE leukemia after bone marrow transplantation for severe aplastic anemia is a rare event.1 , 2 In previous reports, such leukemia has been shown to originate in host cells.2 We report the development of acute monoblastic leukemia in donor cells nine months after transplantation in a patient with aplastic anemia. We used cytogenetic analysis and a novel application of the polymerase chain reaction (PCR) to show that the leukemia was of donor-cell origin. The donor was hematologically normal at the time of transplantation and has remained so to the time of this writing 18 months later.Keywords
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