Cooperative Effects in Antibody Formation Produced by Hapten-Specific Delayed Sensitivity
Open Access
- 1 August 1973
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 111 (2) , 410-415
- https://doi.org/10.4049/jimmunol.111.2.410
Abstract
The ability of delayed sensitivity specific for the azobenzenearsonate (ABA) group to function as a carrier cooperating in the production of antibody to another determinant has been demonstrated in guinea pigs. If guinea pigs are primed with bovine serum albumin (BSA) in alum, the cooperative effect produced by a boost with ABA-BSA leads only to γ1-anti-BSA antibody. If animals are primed with BSA in incomplete Freund's adjuvant, some γ2-antibody is produced as well as γ1-antibody. Priming with BSA in complete Freund's adjuvant leads to sufficient self-helper effects so that no increased antibody production is seen as a consequence of ABA helper effects. The ABA helper effect is seen only if animals have ABA-specific delayed sensitivity, not ABA-specific antibody. Best cooperation is achieved when ABA and BSA are covalently linked.Keywords
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