Protection by a Steroid-Spirolactone Against Certain Types of Cardiac Necroses.

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Abstract
Experiments on rats indicate that the antimineralocorticoid steroid-spirolactone 3-(3-keto-7-thioacetoxy-17[beta]-hydroxy-4-androsten-17[alpha] -yl) propanoic acid lactone (Aldactone)[long dash]offers considerable protection against induction of acute, infarct-like, often fatal myocardial necroses normally produced by fluorocortisol plus some sodium salts and stress, alone or in combination.