A Convenient Conversion of α-Aminoacids into NH-Boc Protected α-Aminoketones via Imidazolides
- 1 September 1998
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1998 (9) , 1013-1015
- https://doi.org/10.1055/s-1998-1831
Abstract
Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.Keywords
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