Untersuchungen zur Iodierung von 4‐Amino‐2,6‐dimethyl‐pyrimidinen – eine Möglichkeit zur regiospezifischen Funktionalisierung

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Abstract
Studies on the Iodination of 4‐Amino‐2,6‐dimethylpyrimidine — A Possibility of the Regiospecific FunctionalizationThe iodination of 4‐amino‐2,6‐dimethyl‐pyrimidine 1a with I2/H2SO4/H2O/H2O2 does not give, as supposed hitherto, the 5‐iodo derivative (2) but affords the corresponding 2‐iodomethyl derivative 3a. The reaction pathway of the iodination is discussed. The reaction of 3a with nucleophiles leads to a variety of side chain‐substituted pyrimidines 5a–j.