BIOCHEMICAL EFFECTS OF NEONATAL TESTOSTERONE TREATMENT ON FEMALE RAT HYPOTHALAMUS DURING POSTNATAL-DEVELOPMENT .1. DNA-SYNTHESIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (1-2) , 13-22
Abstract
The effect of 1 mg testosterone propionate (TP) administered on the 2nd day of life was studied on DNA synthesis in the anterior and posterior parts of the hypothalamus, in the forebrain, anterior pituitary and liver in 5, 7, 14 and 21 day old female rats. As an index of DNA synthesis the rate of 2-14C-thymidine (40 .mu.Ci/100 g body wt) incorporation into DNA was measured 1 h after a s.c. injection. As an effect of TP treatment in both hypothalamic regions the rate of thymidine incorporation into DNA, markedly decreased during the first 2 wk of life, while at 21 days no difference from the control value was found. In the anterior pituitary the rate of DNA synthesis also decreased at 5 and 7 days, but at 14 and 21 days the values were similar to the controls. TP treatment had no effect on the rate of DNA synthesis in the forebrain or in the liver.

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