ABSORPTION-COEFFICIENT OF DIETARY CHOLESTEROL - FUNDAMENTAL PARAMETER OF CHOLESTEROL DYNAMIC EQUILIBRIUM IN RAT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (4) , 205-208
Abstract
Using an isotopic equilibrium method, turnover rates of rat cholesterol were determined in 30 various experimental conditions. Deductive analysis of the overall data shows that the absorption coefficient of dietary cholesterol is a determinative parameter of cholesterol dynamic equilibrium. Synthesis takes place chiefly in the intestine. Fecal external secretion and fecal excretion of cholesterol increase linearly when the absorption coefficient decreases. Two exceptions were noted where there is a supplementary synthesis. In pregnant or lactating female rats, the placenta or mammary glands are directly involved. For rats with a ligated bile duct or fed with cholestyramine, the liver must be involved. These 2 cases are the only ones out of 30 where hepatic synthesis probably has a notable role in the dynamic equilibrium of cholesterol.

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