Heterogeneous Expression of Dipeptidyl-Amino-Peptidase (DAP IV) in T-Cell Chronic Lymphocytic Leukemia
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 71 (4) , 277-281
- https://doi.org/10.1159/000206600
Abstract
The reactivity for the enzyme dipeptidyl-amino-peptidase IV (DAP IV) has been correlated, in 8 cases of T-cell chronic lymphocytic leukemia (T-CLL), with the cellular phenotype as well as the morphological and clinical behaviour of disease. A highly reproducible correspondence between the ‘helper’ phenotype (OKT4+/Fcμ-R+) and DAP IV expression was observed in cases with aggressive disease, whereas the cases with OKT8VFcμ-R+ phenotype were characterized by a favorable prognosis, LGL (large granular lymphocyte) morphology, and were virtually negative for DAP IV.Keywords
This publication has 1 reference indexed in Scilit:
- Functional properties of T cells in patients with chronic T gamma lymphocytosis and chronic T cell neoplasia.The Journal of Immunology, 1982