EFFECT OF SEROTONIN GIVEN INTO LATERAL VENTRICLE OF BRAIN ON SERUM TSH LEVEL IN NORMAL AND THYROXINE-BLOCKED RATS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 70  (3) , 321-325
Abstract
The effect of serotonin given in the lateral ventricle of the brain in rats was investigated. Serotonin was dissolved in artificial cerebrospinal fluid and administered in 3 doses: 250 .mu.g, 50 .mu.g, 10 .mu.g. Only the highest dose of serotonin caused a statistically significant increase in serum TSH [thyrotropin] level 0.5 h after injection. The possible role of serotonin in the blocking mechanism of thyroid hormones on TSH secretion was also taken into consideration. Serotonin 50 .mu.g significantly strengthened the lowering effect on serum TSH of 1-thyroxine given 0.5 h before.

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