Precursors of Urinary 11-Oxy-17-Ketosteroids. II. Allo-3α-tetrahydrocortisol1
- 1 August 1971
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 33 (2) , 176-181
- https://doi.org/10.1210/jcem-33-2-176
Abstract
The role of allo-3α-tetrahydrocortisol (ATHF) as a precursor of 11-hydroxy- and 11-ketoandrosterone was investigated by intravenous administration of 3H-labeled ATHF to 6 human subjects. The conversion ranged from less than 0.8 to 7.4%. This suggests that ATHF does not contribute significantly to urinary 5α,11-oxy-17-ketosteroids, and that 11-hydroxyandrosterone may be used to estimate the production of 11β-hydroxyandrostenedione, either from the quantity of OHA excreted, or, more definitively, from production rate calculations based on the simultaneous injection of labeled cortisol and 11β-hydroxyandrostenedione.Keywords
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