SUPPRESSION OF LACTATION WITH ETHINYL ESTRADIOL

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Abstract
THE estrogens have proved their usefulness in the control of painful breast engorgement in the immediate postpartum period and in the early suppression of lactation. However, the ideal product, dosage and time of administration have not been reached. An attempt has been made in this study to evaluate the usefulness of ethinyl estradiol for the suppression of lactation after other measures had been discarded for either increased secondary uterine bleeding or for ineffectiveness. In 1933, Smith and Smith (1) demonstrated the inhibition of lactation in laboratory animals with the use of large doses of estrin. From this point, extensive trials (2–8) were undertaken with oral and parenteral administration to determine the worth of both the natural and the synthetic substances of estrogen potency. The earliest study with ethinyl estradiol was reported by Kurzrok, Livingston and Birnberg (9) in 1942. Their observations on a series of 59 puerperal women showed promising results.

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