An enantioselective Baylis–Hillman reaction catalyzed by chiral phosphines under atmospheric pressure

1 January 1998

journal article
research article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 12,p. 1271-1272
https://doi.org/10.1039/a802594k

Abstract

2,2’-Bis(diphenylphosphino)-1,1’-binaphthyl (BINAP) catalyzes the enantioselective Baylis–Hillman reaction between pyrimidine- 5-carbaldehydes and acrylates to provide chiral α-methylene β-hydroxy esters in up to 44% ee under atmospheric pressure.

Keywords

ENANTIOSELECTIVE BAYLIS
HILLMAN
BINAPHTHYL
PHOSPHINES
BIS
METHYLENE
CARBALDEHYDES

This publication has 0 references indexed in Scilit: