PREVENTION BY A NEW SYNTHETIC STABLE ANALOG OF PROSTACYCLIN OF THE GASTRIC-LESIONS DUE TO RESTRAINT-COLD STRESS
- 1 January 1986
- journal article
- research article
- Vol. 36-1 (3) , 482-483
Abstract
A new synthetic stable analog of prostacyclin (ZK 36 374, Iloprost) has been shown to inhibit gastric lesions due to restraint-cold stress in rats in a dose-dependent manner. Therefore substitution of the decreased prostacyclin in the gastric mucosa may play an important role in the prevention or treatment of gastric ulcers.This publication has 2 references indexed in Scilit:
- The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) ? Equipotent to PGI2 in vitroNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1981
- Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitroProstaglandins, 1978