STUDIES ON HYPERACTIVITY IN RATS GIVEN TRANYLCYPROMINE STEREOISOMERS AND RESERPINE

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 229  (1) , 129-132
Abstract
Hyperactivity, salivation, piloerection, exophthalmia and ejaculation occurred in rats given reserpine (5 mg/kg i.p.) 2 h after an oral dose (5 mg/kg) of trans-dl-2-phenylcyclopropylamine (tranylcypromine, dl-Tcp). The same syndrome occurred in rats given the d-isomer (d-Tcp) plus reserpine but not in rats given the l-isomer (l-Tcp) plus reserpine. Neither .alpha. methyl-p-tyrosine (2 .times. 150 mg/kg s.c.) nor p-chlorophenylalanine (200 mg/kg s.c.) pretreatment prevented the hyperactivity syndrome. Mainly MAO [monoamine oxidase] inhibition and release of monoamines may be involved in the hyperactivity syndrome produced by dl-Tcp plus reserpine.