The association of clinical conditions and serologic tests with CD4 + lymphocyte counts in HIV-infected subjects without AIDS

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Abstract
Early intervention guidelines in HIV infection require knowledge of CD4+ lymphocyte count; however, CD4 + determinations require special laboratory procedures and may not be readily available in all situations. Using data from 207 HIV-seropositive homosexual men without AIDS, we evaluated the association of difference clinical conditions or serologic tests with CD4+ count. Men with conditions including seborrheic dermatitis, hairy leukoplakia, oral candidiasis and chronic diarrhea, and men with beta2-microglobulin levels ≥4.0mg/l had significantly lower CD4 + counts. However, the probability that a subject with such parameters had 6/I CD4+ cells was limited (25–63%). Although the probability that a subject with such parameters had 6/I CD4+ cells was better (76–88%), the probability that a person without these parameters had ≥500 × 106/I CD4 + cells was only 45–50%. Clinical and serologic parameters may provide important prognostic information, but cannot be used to reliably determine the level of CD4+ cells.

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