The Potential Use of Stem Cells for Cochlear Repair
- 27 February 2004
- journal article
- review article
- Published by S. Karger AG in Audiology and Neurotology
- Vol. 9 (2) , 72-80
- https://doi.org/10.1159/000075998
Abstract
In light of the currently defined characteristics of stem cells, a re-evaluation of hair cell regeneration in birds suggests that there may be a stem cell population located in the inner ear. It is yet to be determined if the mammalian cochlea contains stem cells, but the presence of a mammalian vestibular stem cell population would not appear to be out of the realm of possibility. This paper reviews the latest advances in stem cell biology and suggests that stem cells may be an appropriate biological tool to be used for cochlear repair. The potential use of several types of stem cells, including embryonic, neural and hematopoietic stem cells, as agents for cochlear repair is examined.Keywords
This publication has 48 references indexed in Scilit:
- 2002 Snowbird Conference: Stem cells for tolerance and tissue regeneration: In memory of Professor William H BurnsBone Marrow Transplantation, 2003
- Gene- and cell-based therapeutics for type I diabetes mellitusGene Therapy, 2003
- Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem CellsScience, 2002
- From Gene Identification to Gene TherapyAudiology and Neurotology, 2002
- Sequential Interactions of Fibroblast Growth Factor-2, Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Their Receptors Define Critical Periods in the Development of Cochlear Ganglion CellsExperimental Neurology, 2002
- Cardiac stem cellsThe Journal of Pathology, 2002
- Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone MarrowScience, 2000
- Neurobiology of diseaseCurrent Opinion in Neurobiology, 2000
- Functional Recovery in the Avian Ear after Hair Cell RegenerationAudiology and Neurotology, 1999
- Structural Recovery from Sound and Aminoglycoside Damage in the Avian CochleaAudiology and Neurotology, 1999