New Dopaminergic and Indoleamine-accumulating Cells in the Growth Zone of Goldfish Retinas After Neurotoxic Destruction

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Abstract
Juvenile goldfish were allowed to grow for 3 months after dopaminergic or indoleamine-accumulating cells in their retinas had been destroyed by intravitreal injection of 6-hydroxydopamine or 5,7-dihydroxytryptamine, respectively. New cells of each type were found growing in concentric rings at the margin of the retina. To compensate for the loss of dopaminergic innervation in retinas treated with 6-hydroxydopamine, cells in the growth zone appeared to proliferate at a higher rate than those in untreated retinas and long processes were extended into the retina by the first dopaminergic cells to appear.