Aggregation-Induced Folding of a De Novo Designed Polypeptide Immobilized on Gold Nanoparticles
- 31 January 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (7) , 2194-2195
- https://doi.org/10.1021/ja057056j
Abstract
This communication reports the first steps in the construction of a novel, nanoparticle-based hybrid material for biomimetic and biosensor applications. Gold nanoparticles were modified with synthetic polypeptides to enable control of the particle aggregation state in a switchable manner, and particle aggregation was, in turn, found to induce folding of the immobilized peptides.Keywords
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