Steroids and related studies. Part 44. 17a-Methyl-3β-(N-pyrrolidinyl)17a-aza-D-homo-5α-androstane bis(methiodide)(dihydrochandonium iodide) and certain other analogues of chandonium iodide
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 305-307
- https://doi.org/10.1039/p19790000305
Abstract
The bisquaternary analogues 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5α-androstane bismethiodide (dihydrochandonium iodide)(4), 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homo-5α-androstane bisethiodide (5), 17a-methyl-3β-(N-pyrrolidinyl)-17a-aza-D-homoandrost-5-ene bisethiodide (2), and 17a-ethyl-3β-(N-pyrrolidinyl)-17a-aza-D-homoandrost-5-ene bisethiodide (3) related to chandonium iodide (1) have been prepared. 5,6-Saturation and increase in 'onium bulk decrease the neuromuscular blocking potency; however, dihydrochandonium iodide (4) appears to be a promising compound for further study.This publication has 0 references indexed in Scilit: