The Stoichiometry or Na ‐ Ca + K Exchange in Rod Outer Segments Isolated from Bovine Retinasa
- 17 December 1991
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 639 (1) , 10-21
- https://doi.org/10.1111/j.1749-6632.1991.tb17285.x
Abstract
Ca2+ extrusion in the outer segments of retinal rods (ROS) is mediated by a protein that couples both the inward Na+ gradient and the outward K+ gradient to Ca2+ extrusion. Na(+)-stimulated Ca2+ release from ROS requires internal K+ and is accompanied by release of internal K+, whereas a slow component of Na(+)-stimulated Ca2+ release does not require K+. In this paper we discuss our observations on the K+ transport via Na-Ca+ K exchange in bovine ROS, on the electrogenicity and stoichiometry of the ROS Na-Ca+ K exchanger, and on the mechanism on coupling Ca2+ to K+ via this protein. Finally, we discuss briefly the physiological implications of Na-Ca+ K exchange.Keywords
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