Halogenoalkyl Isocyanates as Bifunctional Reagents in an Aza-Wittig/Heterocyclization Reaction on the Solid Phase: Efficient Entry into New Tetracyclic Benzimidazole Systems
- 6 February 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 6 (2) , 220-223
- https://doi.org/10.1021/cc030036y
Abstract
An efficient one-pot procedure for the solid-phase synthesis of new tetracyclic 1,3,5-triazino[1,2-a]benzimidazolium derivatives starting from resin-bound benzimidazoles is described. The synthetic strategy involves an unprecedented one-pot Aza-Wittig/heterocyclization/substitution reaction sequence using halogenoalkyl isocyanates. The structure of the tetracyclic ring system was determined by two-dimensional NMR experiments and X-ray analysis.Keywords
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