HEMOGLOBIN INHERITANCE IN INBRED MOUSE STRAINS, I. STRUCTURAL DIFFERENCES
Open Access
- 1 September 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (9) , 1505-1513
- https://doi.org/10.1073/pnas.48.9.1505
Abstract
Six different hemoglobins have been isolated from 4 strains of homozygous, inbred mice. Analysis of peptide patterns indicated that 4 different beta chains and 2 different alpha chains were present. Two strains, AKR and FL, contained 2 major hemoglobin types. The separated chains of mouse hemoglobin were similar in C -terminal, N-terminal, and certain internal peptides to the alpha and beta chains of human hemoglobin. Possible evolutionary implications of mouse hemoglobin variations were discussed.Keywords
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