Evidence of Calcitonin-Induced Inhibition of Calcitonin Secretion in Porcine Thyroid Slices

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Abstract
In the present study, the possibility of calcitonin-induced self-inhibition in porcine thyroid slices was examined. Replacing the incubation medium at 5-min intervals during incubation and increasing the volume of incubation from 2 to 15 ml were observed to enhance calcium-stimulated calcitonin secretion in vitro.