In Vivo Tracking of Stem Cells for Clinical Trials in Cardiovascular Disease
- 23 November 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (21) , 3378-3383
- https://doi.org/10.1161/01.cir.0000149840.46523.fc
Abstract
Various stem cells hold promise for the treatment of human cardiovascular disease. Regardless of stem cell origin, future clinical trials will require that the location and number of such cells be tracked in vivo, over long periods of time. The problem of tracking small numbers of cells in the body is a difficult one, and an optimal solution does not yet exist. We review the many contrast agents and detectors that have been proposed for stem cell tracking during clinical trials, define the characteristics of an ideal imaging technology, and suggest future directions for research.Keywords
This publication has 46 references indexed in Scilit:
- The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cellsMolecular Therapy, 2004
- Three-dimensional visualization analysis of in vitro cultured bone fabricated by rat marrow mesenchymal stem cellsBiochemical and Biophysical Research Communications, 2004
- Near-infrared fluorescent type II quantum dots for sentinel lymph node mappingNature Biotechnology, 2003
- LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1Science, 2003
- In VivoTracking of Neural Progenitor Cell Migration to GlioblastomasHuman Gene Therapy, 2003
- PARACEST Agents: Modulating MRI Contrast via Water Proton ExchangeAccounts of Chemical Research, 2003
- Engineering of technetium-99m-binding artificial receptors for imaging gene expressionThe Journal of Gene Medicine, 2003
- Erythropoiesis from acetyl LDL incorporating endothelial cells at the preliver stageBlood, 2003
- Tracking Transplanted Stem Cell Migration Using Bifunctional, Contrast Agent-Enhanced, Magnetic Resonance ImagingNeuroImage, 2002
- Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cellsNature Biotechnology, 2001