MICROBIAL TRANSFORMATION OF RAUWOLFIA ALKALOIDS II. 10-

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Abstract
Twelve microorganisms have been shown to be capable of hydroxylating the Rauwolfia alkaloid, yohimbine, at carbon 10. This finding shows that the ability to bring about this change is not limited to a definite taxonomic group but is shared by representatives of the Actinomycetes, Phycomycetes, Ascomycetes and Fungi Imperfecti. The ability to effect the transformation is strain specific. The organisms found to possess this hydroxylating ability are: Streptomyces scabies, S. rimosus, S. venezuelae, S. chrysomallus, S. griseus, S. aureofaciens, Syncephalis nodosum, Cunninghamella blakesleeana, C. baineri, Sordaria fimetaria, Stysanus microsporus, and Trichoderma viride.

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