BIOCHEMICAL AND CLINICAL EFFECTS OF FENCLOFENAC IN THYROTOXICOSIS

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Abstract
Administration of the anti-inflammatory drug fenclofenac (600 mg twice daily) for 28 days to 4 females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 .+-. 8.6 (standard error of the mean) nmol/l before therapy was normalized to 70 .+-. 6.4 nmol/l after administration of the drug for 7 days. Free T4 levels also decreased significantly but not to within the reference range in all subjects. Mean total triiodothyronine (T3) and reverse T3 levels declined from 6.2 .+-. 0.9 nmol/l and 0.63 .+-. 0.2 nmol/l, respectively, before therapy to 3.8 .+-. 0.5 nmol/l and 0.52 .+-. 0.1 nmol/l after 7 days'' treatment but remained consistently elevated in all subjects. Clinical thyroid status remained unchanged despite these marked reductions in circulating thyroid hormone levels, suggesting that fenclofenac was of no therapeutic benefit.